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Several drug delivery systems of BCS Class IV drugs have been approved by the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) for a variety of therapeutic indications as shown in Table 4. Significant expansion of this sector is expected in upcoming years however, the developers have to face significant regulatory. The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability. [1] This system restricts the prediction using the parameters solubility and intestinal permeability. 
Biopharmaceutics Classification System. Class 4: Low Solubility – Low Permeability. In addition, some IR solid oral dosage forms are categorized as having rapid or very rapid. Dec 22, 2017 FDA has issued a final guidance entitled Waiver of In-vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Oral Dosage Forms Based on a Biopharmaceutics Classification System.
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From HiHiSoft: YouTube Music Downloader is an easy-to-use Windows application downloads YouTube music videos to your PC and converting them into MP3 and more media formats. You can download millions of music from YouTube and listen them on your iPod, MP3 Player or watch them on your PC, iPod, iPhone. Now YouTube Music Downloader supports the latest HD/Vorbis MP4 video format download.
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